Introducing Combunox
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COMBUNOX offers the strength of oxycodone and ibuprofen COMBUNOX offers the strength of oxycodone and ibuprofen1
COMBUNOX offers the strength of oxycodone and ibuprofen
COMBUNOX provides increased analgesia along with the anti-inflammatory properties of ibuprofen—at 400 mg, the highest dose available in a combination opioid product COMBUNOX provides increased analgesia along with the anti-inflammatory properties of ibuprofen—at 400 mg, the highest dose available in a combination opioid product
COMBUNOX provides increased analgesia along with the anti-inflammatory properties of ibuprofen—at 400 mg, the highest dose available in a combination opioid product
COMBUNOX delivers significant pain relief and a reduction in pain intensity (P<0.05) COMBUNOX delivers significant pain relief and a reduction in pain intensity (P<0.05)
COMBUNOX delivers significant pain relief and a reduction in pain intensity (P<0.05)
  †As shown in postoperative pain models
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References:
1. COMBUNOX® (Oxycodone HCl and Ibuprofen) Tablets Prescribing Information. Forest Pharmaceuticals, Inc., St Louis, Mo.
2. Singla N, Pong A, Newman K, for the MD-10 Study Group. Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study. Clin Ther. 2005;27:45–57.
3. Newman K, Zheng H. Combination of oxycodone HCl and ibuprofen, compared to ibuprofen or oxycodone HCl alone, is more rapid and effective in alleviating postoperative pain. Presented at: 22nd Annual Scientific Meeting of the American Pain Society; March 20–23, 2003; Chicago, Ill.
4. Data on file, Forest Laboratories, Inc.
5. Litkowski LJ, Christensen SE, Adamson DN, Van Dyke T, Han S-H, Newman K. Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blind, placebo-controlled, single-dose, parallel-group study in a dental pain model. Clin Ther. 2005;27:418–429.